Triamcinolone Acetonide

For research use only. Not for therapeutic Use.

  • CAT Number: A000642
  • CAS Number: 76-25-5
  • Molecular Formula: C24H31FO6
  • Molecular Weight: 434.50
  • Purity: ≥95%
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Triamcinolone Acetonide (Cat No.:A000642) is a synthetic corticosteroid with potent anti-inflammatory, antipruritic, and immunosuppressive properties. It is commonly used to treat a variety of skin conditions, allergic reactions, and inflammatory disorders such as eczema, psoriasis, and arthritis. Available in topical, injectable, and inhalable forms, it reduces inflammation by inhibiting cytokine production and immune cell activation. Its long-acting formulation allows for sustained relief, especially in joint or intralesional injections. Careful use is required to avoid side effects like skin thinning or adrenal suppression.


CAS Number 76-25-5
Synonyms

76-25-5; Azmacort; Aristoderm; Aristogel; Kenalone

Molecular Formula C24H31FO6
Purity ≥95%
Target Vitamin D Related/Nuclear Receptor
Storage -20°C
InChI InChI=1S/C24H31FO6/c1-20(2)30-19-10-16-15-6-5-13-9-14(27)7-8-21(13,3)23(15,25)17(28)11-22(16,4)24(19,31-20)18(29)12-26/h7-9,15-17,19,26,28H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,21-,22-,23-,24+/m0/s1
InChIKey YNDXUCZADRHECN-JNQJZLCISA-N
SMILES CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)CO)C)O)F)C)C
Reference

1: van Heugten AJP, de Boer W, de Vries WS, Markesteijn CMA, Vromans H.
Development and validation of a stability-indicating HPLC-UV method for the
determination of triamcinolone acetonide and its degradation products in an
ointment formulation. J Pharm Biomed Anal. 2017 Nov 7;149:265-270. doi:
10.1016/j.jpba.2017.11.026. [Epub ahead of print] PubMed PMID: 29127908.
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2: Chauhan P, De D, Handa S, Narang T, Saikia UN. A prospective observational
study to compare efficacy of topical triamcinolone acetonide 0.1% oral paste,
oral methotrexate, and a combination of topical triamcinolone acetonide 0.1% and
oral methotrexate in moderate to severe oral lichen planus. Dermatol Ther. 2017
Nov 10. doi: 10.1111/dth.12563. [Epub ahead of print] PubMed PMID: 29124831.

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3: Al Hinai A, Wali UK, Rasool TA, Rizvi SG. Experience of intravitreal
triamcinolone acetonide for treatment of diabetic macular edema among Omani
population. Oman J Ophthalmol. 2017 Sep-Dec;10(3):177-183. doi:
10.4103/ojo.OJO_173_2016. PubMed PMID: 29118493; PubMed Central PMCID:
PMC5657160.

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4: Aval SF, Zarghami N, Alizadeh E, Mohammadi SA. The effect of ketorolac and
triamcinolone acetonide on adipogenic and hepatogenic differentiation through
miRNAs 16/15/195: Possible clinical application in regenerative medicine. Biomed
Pharmacother. 2017 Nov 1;97:675-683. doi: 10.1016/j.biopha.2017.10.126. [Epub
ahead of print] PubMed PMID: 29101812.

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5: Srivastava S, Patil AN, Prakash C, Kumari H. Comparison of Intralesional
Triamcinolone Acetonide, 5-Fluorouracil, and Their Combination for the Treatment
of Keloids. Adv Wound Care (New Rochelle). 2017 Nov 1;6(11):393-400. doi:
10.1089/wound.2017.0741. PubMed PMID: 29098115; PubMed Central PMCID: PMC5665091.
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6: Conaghan PG, Cohen SB, Berenbaum F, Lufkin J, Johnson JR, Bodick N. Phase 2b
trial of a novel extended-release microsphere formulation of triamcinolone
acetonide for intra-articular injection in knee osteoarthritis. Arthritis
Rheumatol. 2017 Oct 31. doi: 10.1002/art.40364. [Epub ahead of print] PubMed
PMID: 29088579.
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7: Liebmann P, Vorstandlechner V, Radtke C. Comment: A Prospective Randomized
Trial of the Efficacy of Fibrin Glue, Triamcinolone Acetonide and Quilting
Sutures in Seroma Prevention after Latissimus Dorsi Breast Reconstruction. Plast
Reconstr Surg. 2017 Oct 13. doi: 10.1097/PRS.0000000000004032. [Epub ahead of
print] PubMed PMID: 29068895.

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8: Kraus VB, Conaghan PG, Aazami HA, Mehra P, Kivitz AJ, Lufkin J, Hauben J,
Johnson JR, Bodick N. Synovial and systemic pharmacokinetics (PK) of
triamcinolone acetonide (TA) following intra-articular (IA) injection of an
extended-release microsphere-based formulation (FX006) or standard crystalline
suspension in patients with knee osteoarthritis (OA). Osteoarthritis Cartilage.
2017 Oct 9. pii: S1063-4584(17)31226-8. doi: 10.1016/j.joca.2017.10.003. [Epub
ahead of print] PubMed PMID: 29024802.
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9: Ashraf J, Radford AR, Turner A, Subramaniam R. Preliminary Experience with
Instillation of Triamcinolone Acetonide into the Urethra for Idiopathic
Urethritis: A Prospective Pilot Study. J Laparoendosc Adv Surg Tech A. 2017
Nov;27(11):1217-1221. doi: 10.1089/lap.2017.0064. Epub 2017 Oct 12. PubMed PMID:
29023188.
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10: Sar-Pomian M, Czuwara J, Grygorowicz T, Mirowska-Guzel D,
Cudnoch-Jedrzejewska A, Rudnicka L, Olszewska M. Efficacy of perilesional and
intralesional triamcinolone acetonide injections in pemphigus vulgaris lesions of
the scalp: an effective therapeutic option. Clin Exp Dermatol. 2017 Oct 10. doi:
10.1111/ced.13288. [Epub ahead of print] PubMed PMID: 28994133.

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