For research use only. Not for therapeutic Use.
Trequinsin hydrochloride（Cat No.:I010541）is a potent, cell-permeable phosphodiesterase (PDE) inhibitor with strong selectivity for PDE3 and additional activity against PDE2 and PDE4. By preventing the breakdown of cyclic nucleotides, it elevates intracellular cAMP and cGMP levels, thereby enhancing vasodilation, platelet inhibition, and positive inotropic effects. Trequinsin hydrochloride has been widely used in cardiovascular research to study heart contractility, vascular function, and platelet aggregation. Its multitarget PDE inhibition also makes it valuable for investigating signaling pathways in cancer, inflammation, and neurological disorders where cyclic nucleotide regulation is critical.
| CAS Number | 78416-81-6 |
| Synonyms | 9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one;hydrochloride |
| Molecular Formula | C24H28ClN3O3 |
| Purity | ≥95% |
| IUPAC Name | 9,10-dimethoxy-3-methyl-2-(2,4,6-trimethylphenyl)imino-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one;hydrochloride |
| InChI | InChI=1S/C24H27N3O3.ClH/c1-14-9-15(2)23(16(3)10-14)25-22-13-19-18-12-21(30-6)20(29-5)11-17(18)7-8-27(19)24(28)26(22)4;/h9-13H,7-8H2,1-6H3;1H |
| InChIKey | DTCZZBVPTHVXFA-UHFFFAOYSA-N |
| SMILES | CC1=CC(=C(C(=C1)C)N=C2C=C3C4=CC(=C(C=C4CCN3C(=O)N2C)OC)OC)C.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
