For research use only. Not for therapeutic Use.
TREM-1 Inhibitory Peptide M3(CAT: I040250) is a ligand-dependent antagonist of Triggering Receptor Expressed on Myeloid cells-1 (TREM-1), a key amplifier of inflammatory responses. M3 effectively suppresses the production of systemic and pulmonary pro-inflammatory cytokines and chemokines, making it a valuable research tool for studying innate immune modulation. In preclinical models, this peptide significantly attenuates acute lung injury (ALI) and associated inflammation, highlighting its therapeutic potential in sepsis, respiratory distress syndromes, and other inflammatory conditions. TREM-1 Inhibitory Peptide M3 supports investigations into inflammation resolution, immune cell signaling, and cytokine storm mitigation.
| Synonyms | 2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]acetic acid |
| Molecular Formula | C36H53N13O8 |
| Purity | ≥95% |
| IUPAC Name | 2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]acetic acid |
| InChI | InChI=1S/C36H53N13O8/c37-24(13-7-15-42-35(38)39)31(54)45-20-29(51)47-26(17-22-9-3-1-4-10-22)33(56)49-27(18-23-11-5-2-6-12-23)34(57)48-25(14-8-16-43-36(40)41)32(55)46-19-28(50)44-21-30(52)53/h1-6,9-12,24-27H,7-8,13-21,37H2,(H,44,50)(H,45,54)(H,46,55)(H,47,51)(H,48,57)(H,49,56)(H,52,53)(H4,38,39,42)(H4,40,41,43)/t24-,25-,26-,27-/m0/s1 |
| InChIKey | AEMLCJQUJBKKDK-FWEHEUNISA-N |
| SMILES | C1=CC=C(C=C1)CC(C(=O)NC(CC2=CC=CC=C2)C(=O)NC(CCCN=C(N)N)C(=O)NCC(=O)NCC(=O)O)NC(=O)CNC(=O)C(CCCN=C(N)N)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
