TRC-766

For research use only. Not for therapeutic Use.

  • CAT Number: I045459
  • CAS Number: 1810734-44-1
  • Molecular Formula: C25H24ClF3N2O3S
  • Molecular Weight: 524.98
  • Purity: ≥95%
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TRC-766 (Cat No.: I045459) is a small-molecule inhibitor targeting hypoxia-inducible factor prolyl hydroxylases (HIF-PHDs), enzymes that regulate the stability of hypoxia-inducible factors (HIFs) by promoting their degradation under normoxic conditions. By inhibiting HIF-PHDs, TRC-766 stabilizes HIF-α subunits, enhancing transcription of hypoxia-responsive genes involved in angiogenesis, erythropoiesis, and metabolic adaptation. It is used in research to study hypoxia signaling pathways and evaluate potential therapeutic applications in anemia, ischemic diseases, and wound healing, where activation of HIF-mediated responses may provide protective and regenerative benefits.


CAS Number 1810734-44-1
Synonyms

N-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methyl-4-(trifluoromethoxy)benzenesulfonamide

Molecular Formula C25H24ClF3N2O3S
Purity ≥95%
InChI InChI=1S/C25H24ClF3N2O3S/c1-30(35(32,33)22-13-11-21(12-14-22)34-25(27,28)29)15-4-16-31-23-6-3-2-5-18(23)7-8-19-9-10-20(26)17-24(19)31/h2-3,5-6,9-14,17H,4,7-8,15-16H2,1H3
InChIKey HXSYJRNSDWIKPO-UHFFFAOYSA-N
SMILES CN(CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)OC(F)(F)F
Reference

[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080.
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