For research use only. Not for therapeutic Use.
TRC-766 (Cat No.: I045459) is a small-molecule inhibitor targeting hypoxia-inducible factor prolyl hydroxylases (HIF-PHDs), enzymes that regulate the stability of hypoxia-inducible factors (HIFs) by promoting their degradation under normoxic conditions. By inhibiting HIF-PHDs, TRC-766 stabilizes HIF-α subunits, enhancing transcription of hypoxia-responsive genes involved in angiogenesis, erythropoiesis, and metabolic adaptation. It is used in research to study hypoxia signaling pathways and evaluate potential therapeutic applications in anemia, ischemic diseases, and wound healing, where activation of HIF-mediated responses may provide protective and regenerative benefits.
CAS Number | 1810734-44-1 |
Synonyms | N-[3-(2-chloro-5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl]-N-methyl-4-(trifluoromethoxy)benzenesulfonamide |
Molecular Formula | C25H24ClF3N2O3S |
Purity | ≥95% |
InChI | InChI=1S/C25H24ClF3N2O3S/c1-30(35(32,33)22-13-11-21(12-14-22)34-25(27,28)29)15-4-16-31-23-6-3-2-5-18(23)7-8-19-9-10-20(26)17-24(19)31/h2-3,5-6,9-14,17H,4,7-8,15-16H2,1H3 |
InChIKey | HXSYJRNSDWIKPO-UHFFFAOYSA-N |
SMILES | CN(CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl)S(=O)(=O)C4=CC=C(C=C4)OC(F)(F)F |
Reference | [1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080. |
Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |