Transketolase-IN-3

For research use only. Not for therapeutic Use.

  • CAT Number: I042602
  • CAS Number: 2757552-03-5
  • Molecular Formula: C20H9ClF3NO3
  • Molecular Weight: 403.74
  • Purity: ≥95%
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Transketolase-IN-3 (Cat No.: I042602) is a selective inhibitor of transketolase, a key enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). By targeting transketolase, this compound disrupts nucleotide biosynthesis and redox balance, making it a valuable tool for studying cancer metabolism and oxidative stress. Transketolase-IN-3 helps elucidate the role of PPP in tumor growth and metabolic reprogramming. It is particularly useful in exploring therapeutic strategies aimed at limiting cancer cell proliferation by impairing metabolic flexibility and antioxidant defense mechanisms.


CAS Number 2757552-03-5
Synonyms

2-[2-chloro-4-(trifluoromethyl)benzoyl]benzo[de]isoquinoline-1,3-dione

Molecular Formula C20H9ClF3NO3
Purity ≥95%
InChI InChI=1S/C20H9ClF3NO3/c21-15-9-11(20(22,23)24)7-8-12(15)17(26)25-18(27)13-5-1-3-10-4-2-6-14(16(10)13)19(25)28/h1-9H
InChIKey MQJOKZYPUSULEI-UHFFFAOYSA-N
SMILES C1=CC2=C3C(=C1)C(=O)N(C(=O)C3=CC=C2)C(=O)C4=C(C=C(C=C4)C(F)(F)F)Cl
Reference

[1]. Yan-En Wang, et al. Design, Synthesis, and Herbicidal Activity of Naphthalimide-Aroyl Hybrids as Potent Transketolase Inhibitors. J Agric Food Chem
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