For research use only. Not for therapeutic Use.
Transketolase-IN-2 (Cat No.: I042603) is a potent inhibitor of transketolase, an essential enzyme in the non-oxidative branch of the pentose phosphate pathway (PPP). By blocking transketolase activity, this compound interferes with the production of ribose-5-phosphate and NADPH, crucial for nucleotide synthesis and redox homeostasis. Transketolase-IN-2 is a valuable tool for investigating metabolic vulnerabilities in cancer cells, particularly those reliant on PPP for growth and survival. It supports research into targeting metabolic pathways to impair tumor progression and enhance therapeutic outcomes.
| CAS Number | 2757552-21-7 |
| Synonyms | 2-[2-methyl-4-(trifluoromethyl)-1,3-thiazole-5-carbonyl]benzo[de]isoquinoline-1,3-dione |
| Molecular Formula | C18H9F3N2O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C18H9F3N2O3S/c1-8-22-14(18(19,20)21)13(27-8)17(26)23-15(24)10-6-2-4-9-5-3-7-11(12(9)10)16(23)25/h2-7H,1H3 |
| InChIKey | DSBLHEOFYWPYFY-UHFFFAOYSA-N |
| SMILES | CC1=NC(=C(S1)C(=O)N2C(=O)C3=CC=CC4=C3C(=CC=C4)C2=O)C(F)(F)F |
| Reference | [1]. Wang YE, et al. Design, Synthesis, and Herbicidal Activity of Naphthalimide-Aroyl Hybrids as Potent Transketolase Inhibitors. J Agric Food Chem. 2022 Oct 12;70(40):12819-12829. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
