For research use only. Not for therapeutic Use.
trans-Doxercalciferol(CAT: R046511) is a synthetic vitamin D₂ analog and prohormone that undergoes hepatic activation to form 1α-hydroxyvitamin D₂, an active metabolite regulating calcium and phosphorus homeostasis. As a selective vitamin D receptor (VDR) agonist, trans-Doxercalciferol modulates gene transcription involved in mineral metabolism, parathyroid hormone (PTH) regulation, and bone health. It is widely studied in models of secondary hyperparathyroidism, chronic kidney disease, and metabolic bone disorders. With reduced risk of hypercalcemia compared to other vitamin D analogs, trans-Doxercalciferol provides a valuable tool for investigating vitamin D signaling, endocrine regulation, and potential therapeutic strategies for calcium-phosphate imbalance and skeletal disease research.
| CAS Number | 74007-20-8 |
| Synonyms | (1R,3S,5E)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| Molecular Formula | C28H44O2 |
| Purity | ≥95% |
| IUPAC Name | (1R,3S,5E)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| InChI | InChI=1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12+/t19-,20+,24+,25+,26-,27-,28+/m0/s1 |
| InChIKey | HKXBNHCUPKIYDM-HBZIUUSASA-N |
| SMILES | CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
