trans-4-Hydroxy-L-proline

• CAT Number: R050109
• CAS Number: 51-35-4
• Molecular Formula: C5H9NO3
• Molecular Weight: 131.13
• Purity: ≥95%
• Synonyms: (-)-4-Hydroxy-2-pyrrolidinecarboxylic Acid; (2S,4R)-(-)-4-Hydroxyproline; (R)-4-Hydroxy-(S)-proline; 4(R)-Hydroxy-2(S)-pyrrolidinecarboxylic Acid; 4-trans-Hydroxy-L-proline; L-Hypro; NSC 46704
• Storage: Store at RT
• IUPAC Name: (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid
• InChI: InChI=1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
• InChIKey: PMMYEEVYMWASQN-DMTCNVIQSA-N
• SMILES: C1[C@H](CN[C@@H]1C(=O)O)O

trans-4-Hydroxy-L-proline（Cat No.:R050109）is a naturally occurring amino acid derivative, primarily found in collagen, where it plays a critical role in stabilizing the triple-helix structure. It is formed by the post-translational hydroxylation of the amino acid proline and exists in the trans configuration, enhancing collagen’s thermal stability. This compound is often used in biochemical research, collagen synthesis studies, and peptide synthesis. It appears as a white crystalline powder, is water-soluble, and exhibits zwitterionic properties. trans-4-Hydroxy-L-proline also serves as a building block in pharmaceuticals and as a chiral intermediate in synthetic organic chemistry.

Reference

1. Tetrahedron Letters 35, 6163-6163, (1994) 
2. Tetrahedron 49,6195-6195, (1993)
3. Synthetic Communications 23, 2691-2691, (1993)