Tramiprosate

• CAT Number: I003357
• CAS Number: 3687-18-1
• Molecular Formula: C3H9NO3S
• Molecular Weight: 139.2
• Purity: ≥95%
• Target: Amyloid β
• Solubility: 50 mg/mL in H2O
• Storage: 2-8°C
• IUPAC Name: 3-aminopropane-1-sulfonic acid
• InChI: InChI=1S/C3H9NO3S/c4-2-1-3-8(5,6)7/h1-4H2,(H,5,6,7)
• InChIKey: SNKZJIOFVMKAOJ-UHFFFAOYSA-N
• SMILES: C(CN)CS(=O)(=O)O

Tramiprosate (Cat No.:I003357) is a natural amino acid derived from red seaweeds that can cross the blood-brain barrier. It has several pharmacological effects, including binding to soluble amyloid-beta (Aβ) and preventing its aggregation into fibrils, which is associated with Alzheimer’s disease. Tramiprosate is also an analog of gamma-aminobutyric acid (GABA), a neurotransmitter with neuroprotective, anticonvulsant, and antihypertensive properties. Its ability to modulate Aβ and GABA pathways makes it a potential therapeutic option for neurodegenerative disorders.

Reference

[1]. Wu S et al. Tramiprosate protects neurons against ischemic stroke by disrupting the interaction between PSD95 and nNOS. Neuropharmacology. 2014 Aug;83:107-17.
[2]. Aisen PS et al. Tramiprosate in mild-to-moderate Alzheimer/’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study). Arch Med Sci. 2011 Feb;7(1):102-11.