For research use only. Not for therapeutic Use.
Trametiglue (Cat No.: I041301) is a small-molecule inhibitor that targets glutaminase (GLS), a key enzyme in glutamine metabolism. By inhibiting GLS activity, Trametiglue disrupts the conversion of glutamine to glutamate, impairing the TCA cycle and reducing biosynthetic and energy-producing pathways critical for cancer cell proliferation. This compound is especially valuable in studying glutamine-addicted tumors and metabolic reprogramming in cancer. Trametiglue supports research into targeting tumor metabolism as a therapeutic strategy, offering insights into the role of glutaminolysis in disease progression.
| CAS Number | 2666940-97-0 |
| Synonyms | 3-cyclopropyl-5-(2-fluoro-4-iodoanilino)-6,8-dimethyl-1-[3-(methylsulfamoylamino)phenyl]pyrido[4,3-d]pyrimidine-2,4,7-trione |
| Molecular Formula | C25H24FIN6O5S |
| Purity | ≥95% |
| InChI | InChI=1S/C25H24FIN6O5S/c1-13-21-20(22(31(3)23(13)34)29-19-10-7-14(27)11-18(19)26)24(35)33(16-8-9-16)25(36)32(21)17-6-4-5-15(12-17)30-39(37,38)28-2/h4-7,10-12,16,28-30H,8-9H2,1-3H3 |
| InChIKey | DNNMBAWCLGMMRJ-UHFFFAOYSA-N |
| SMILES | CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC=CC(=C4)NS(=O)(=O)NC)C5CC5 |
| Reference | [1]. Khan ZM, et al. Structural basis for the action of the drug trametinib at KSR-bound MEK. Nature. 2020 Dec;588(7838):509-514. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
