TR-14035

• CAT Number: I002770
• CAS Number: 232271-19-1
• Molecular Formula: C24H21Cl2NO5
• Molecular Weight: 474.33
• Purity: ≥95%
• Synonyms: (2S)-2-[(2,6-dichlorobenzoyl)amino]-3-[4-(2,6-dimethoxyphenyl)phenyl]propanoic acid
• Target: Integrin
• Solubility: DMSO：≥ 41 mg/mL
• Storage: Store at -20C
• IC50: alpha(4)beta(7)/alpha(4)beta(1)=7/87 nM [1]

TR-14035 (CAT: I002770) stands out as a dual antagonist targeting both the alpha4beta7 and alpha4beta1 integrins. This compound effectively inhibits the interactions of these integrins with their respective ligands. Specifically, TR-14035 exhibits an IC50 of 7 nM for alpha4beta7 and an IC50 of 87 nM for alpha4beta1 integrin inhibition. These integrins play vital roles in cell adhesion and migration processes, contributing to various physiological and pathological conditions.

Reference

[1]. Sircar I, et al. Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist. Bioorg Med Chem. 2002 Jun;10(6):2051-66.
[2]. Egger LA, et al. Alpha(4)beta(7)/alpha(4)beta(1) dual integrin antagonists block alpha(4)beta(7)-dependent adhesion under shear flow. J Pharmacol Exp Ther. 2002 Jul;302(1):153-62.