For research use only. Not for therapeutic Use.
TPE-MI (Cat No.:I045198) is a fluorescent thiol-reactive probe designed to detect unfolded proteins by covalently labeling exposed cysteine residues. The tetraphenylethene (TPE) core exhibits aggregation-induced emission (AIE), producing strong fluorescence upon binding to target proteins in their aggregated or misfolded states. TPE-MI enables real-time monitoring of protein unfolding, aggregation, and stress responses in live cells or in vitro assays. It is widely used in protein misfolding research, neurodegenerative disease studies, and drug screening. Its high sensitivity, specificity, and photostability make it a powerful tool for proteostasis and molecular chaperone investigations.
| CAS Number | 1245606-71-6 |
| Synonyms | 1-[4-[(Z)-2-(4-methylphenyl)-1,2-diphenylethenyl]phenyl]pyrrole-2,5-dione |
| Molecular Formula | C31H23NO2 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-[(Z)-2-(4-methylphenyl)-1,2-diphenylethenyl]phenyl]pyrrole-2,5-dione |
| InChI | InChI=1S/C31H23NO2/c1-22-12-14-25(15-13-22)30(23-8-4-2-5-9-23)31(24-10-6-3-7-11-24)26-16-18-27(19-17-26)32-28(33)20-21-29(32)34/h2-21H,1H3/b31-30- |
| InChIKey | CIMVFJJQFXGASK-KTMFPKCZSA-N |
| SMILES | CC1=CC=C(C=C1)/C(=C(/C2=CC=CC=C2)\C3=CC=C(C=C3)N4C(=O)C=CC4=O)/C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
