TPC2-A1-P

• CAT Number: I045452
• CAS Number: 2804595-86-4
• Molecular Formula: C20H21BrF3NO3
• Molecular Weight: 460.28
• Purity: ≥95%
• Synonyms: 5-[5-bromo-2-(trifluoromethoxy)phenyl]-1-(cyclohexylmethyl)-2-methylpyrrole-3-carboxylic acid
• InChI: InChI=1S/C20H21BrF3NO3/c1-12-15(19(26)27)10-17(25(12)11-13-5-3-2-4-6-13)16-9-14(21)7-8-18(16)28-20(22,23)24/h7-10,13H,2-6,11H2,1H3,(H,26,27)
• InChIKey: INDFMVADKKBSSU-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(N1CC2CCCCC2)C3=C(C=CC(=C3)Br)OC(F)(F)F)C(=O)O

TPC2-A1-P (Cat No.: I045452) is a selective agonist of two-pore channel 2 (TPC2), an endolysosomal cation channel that regulates calcium and sodium release from acidic organelles. By activating TPC2, TPC2-A1-P modulates intracellular calcium signaling, impacting processes such as endolysosomal trafficking, autophagy, and membrane fusion. It is used in cell biology and pharmacological research to study TPC2’s role in physiological and pathological processes, including cancer, pigmentation, and infectious diseases. TPC2-A1-P serves as a valuable tool for probing endolysosomal signaling pathways and developing TPC2-targeted therapies.

Reference

[1]. Susanne Gerndt, et al. Agonist-mediated switching of ion selectivity in TPC2 differentially promotes lysosomal function. Elife. 2020 Mar 16;9:e54712.
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[2]. Gerndt S, et al. Discovery of lipophilic two-pore channel agonists. FEBS J. 2020;287(24):5284-5293.
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[3]. Xuhui Jin, et al. Targeting Two-Pore Channels: Current Progress and Future Challenges. Trends Pharmacol Sci. 2020 Aug;41(8):582-594.
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