For research use only. Not for therapeutic Use.
TP0586532 (Cat No.: I045422) is a small-molecule inhibitor targeting Clostridioides difficile DNA polymerase IIIC, an essential enzyme for bacterial DNA replication. By selectively binding to Pol IIIC, it blocks DNA synthesis, leading to bacterial cell death. TP0586532 exhibits potent activity against C. difficile with minimal impact on gut microbiota, offering a targeted approach for treating C. difficile infections (CDI) while reducing the risk of recurrence. Its selectivity and narrow-spectrum profile make it a promising candidate for precision antimicrobial therapy in gastrointestinal infectious disease research.
| CAS Number | 2427584-96-9 |
| Synonyms | 4-[(1R,5S)-6-[2-[4-[3-[[2-[(1S)-1-hydroxyethyl]imidazol-1-yl]methyl]-1,2-oxazol-5-yl]phenyl]ethynyl]-3-azabicyclo[3.1.0]hexan-3-yl]butanoic acid |
| Molecular Formula | C26H28N4O4 |
| Purity | ≥95% |
| InChI | InChI=1S/C26H28N4O4/c1-17(31)26-27-10-12-30(26)14-20-13-24(34-28-20)19-7-4-18(5-8-19)6-9-21-22-15-29(16-23(21)22)11-2-3-25(32)33/h4-5,7-8,10,12-13,17,21-23,31H,2-3,11,14-16H2,1H3,(H,32,33)/t17-,21?,22-,23+/m0/s1 |
| InChIKey | PULUMLQUYYSBOR-BOSCWZPRSA-N |
| SMILES | CC(C1=NC=CN1CC2=NOC(=C2)C3=CC=C(C=C3)C#CC4C5C4CN(C5)CCCC(=O)O)O |
| Reference | [1]. Ushiyama F, et al. Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532. Bioorg Med Chem. 2021;30:115964. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
