For research use only. Not for therapeutic Use.
TP0472993 (Cat No.: I042577) is a potent and selective inhibitor of LAT1 (L-type amino acid transporter 1), a transporter highly expressed in cancer cells and involved in the uptake of essential amino acids. By blocking LAT1, TP0472993 disrupts amino acid availability, thereby impairing mTOR signaling and tumor cell proliferation. It serves as a valuable tool for investigating cancer metabolism and nutrient sensing. TP0472993 supports the development of targeted therapies aimed at starving cancer cells by inhibiting nutrient transport pathways critical for tumor growth.
| CAS Number | 2126874-77-7 |
| Synonyms | 1-[4-[[6-(1H-pyrazol-5-yl)pyridin-3-yl]oxymethyl]piperidin-1-yl]ethanone |
| Molecular Formula | C16H20N4O2 |
| Purity | ≥95% |
| InChI | InChI=1S/C16H20N4O2/c1-12(21)20-8-5-13(6-9-20)11-22-14-2-3-15(17-10-14)16-4-7-18-19-16/h2-4,7,10,13H,5-6,8-9,11H2,1H3,(H,18,19) |
| InChIKey | GNQGSUOEYQIORN-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCC(CC1)COC2=CN=C(C=C2)C3=CC=NN3 |
| Reference | [1]. Kawamura M, et, al. Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition. J Med Chem. 2022 Nov 10;65(21):14599-14613. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
