For research use only. Not for therapeutic Use.
TP003（Cat No.:I010952）is a nonbenzodiazepine compound that acts as a positive allosteric modulator at the benzodiazepine site of GABA<sub>A</sub> receptors. It exhibits high affinity for various receptor subtypes, with EC₅₀ values of 3.24 nM for α3β3γ2, 10.6 nM for α2β3γ2, 5.64 nM for α5β2γ2, and 20.3 nM for α1β2γ2 subtypes. TP003 has demonstrated anxiolytic effects, primarily through modulation of α2-containing GABA<sub>A</sub> receptors, and induces muscle relaxation via α3 subtypes. Unlike traditional benzodiazepines, TP003 offers reduced sedative and amnesic side effects, making it a valuable tool in neuropharmacological research..
| CAS Number | 628690-75-5 |
| Synonyms | 5-fluoro-2-[2-fluoro-5-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile |
| Molecular Formula | C23H16F3N3O |
| Purity | ≥95% |
| IUPAC Name | 5-fluoro-2-[2-fluoro-5-[8-fluoro-7-(2-hydroxypropan-2-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]benzonitrile |
| InChI | InChI=1S/C23H16F3N3O/c1-23(2,30)18-7-8-29-20(12-28-22(29)21(18)26)13-3-6-19(25)17(10-13)16-5-4-15(24)9-14(16)11-27/h3-10,12,30H,1-2H3 |
| InChIKey | SJMMDWXJSSJHOQ-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=C(C2=NC=C(N2C=C1)C3=CC(=C(C=C3)F)C4=C(C=C(C=C4)F)C#N)F)O |
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