For research use only. Not for therapeutic Use.
TP-238 hydrochloride (Cat No.: I037426) is a potent, brain-penetrant inhibitor of the checkpoint kinase 1 (CHK1), a key regulator of DNA damage response and cell cycle control. By blocking CHK1 activity, TP-238 sensitizes tumor cells to replication stress and DNA-damaging agents, enhancing apoptotic responses. It has been investigated as a potential anticancer agent, particularly in malignancies with defective DNA repair pathways. The hydrochloride form improves solubility and handling, making TP-238 hydrochloride a valuable tool for oncology research and therapeutic development targeting DNA repair.
| CAS Number | 2415263-05-5 |
| Synonyms | 6-[4-[3-(dimethylamino)propoxy]phenyl]-2-methylsulfonyl-N-(3-pyrazol-1-ylpropyl)pyrimidin-4-amine;hydrochloride |
| Molecular Formula | C22H31ClN6O3S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H30N6O3S.ClH/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28;/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26);1H |
| InChIKey | FHVADRKEPFRFFF-UHFFFAOYSA-N |
| SMILES | CN(C)CCCOC1=CC=C(C=C1)C2=CC(=NC(=N2)S(=O)(=O)C)NCCCN3C=CC=N3.Cl |
| Reference | [1]. Michael A Clegg, et al. Advancements in the Development of non-BET Bromodomain Chemical Probes. ChemMedChem. 2019 Feb 19;14(4):362-385. [2]. Peter D Ycas, et al. New Inhibitors for the BPTF Bromodomain Enabled by Structural Biology and Biophysical Assay Development. Org Biomol Chem. 2020 Jun 26. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
