TP-1454

• CAT Number: I047497
• CAS Number: 2490276-04-3
• Molecular Formula: C19H22F4N4O3S
• Molecular Weight: 462.46
• Purity: ≥95%

TP-1454 is an activator of PKM2 with AC50 of 10 Nm in biochemical assays.TP-1454 modulates tumor-immune responses by destabilizing T-regulatory cells.

Reference

[1] Weagel EG, et al. Med Chem Res 31, 1068–1087 (2022).
[2] Sommakia S, et al. Sumitomo Pharma Oncology, Inc., Lehi, UT