For research use only. Not for therapeutic Use.
TP-060（Cat No.:I044060）is a selective and potent inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK1), a critical regulator of inflammation and programmed necrosis (necroptosis). By blocking RIPK1 activity, TP-060 prevents the activation of downstream necroptotic and inflammatory signaling pathways, including TNF-α-induced cell death. This compound is especially valuable in research on neuroinflammation, autoimmune diseases, and ischemia-reperfusion injury. TP-060 supports therapeutic exploration of cell death modulation and inflammation resolution, offering a promising approach to treating disorders where aberrant necroptosis and cytokine signaling contribute to tissue damage and disease progression.
| CAS Number | 2601393-20-6 |
| Synonyms | 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-[4-(2-hydroxypropan-2-yl)phenyl]-3H-pyrrolo[3,4-c]pyridin-1-one |
| Molecular Formula | C24H20F4N2O3 |
| Purity | ≥95% |
| IUPAC Name | 4-[4-fluoro-2-(2,2,2-trifluoroethoxy)phenyl]-2-[4-(2-hydroxypropan-2-yl)phenyl]-3H-pyrrolo[3,4-c]pyridin-1-one |
| InChI | InChI=1S/C24H20F4N2O3/c1-23(2,32)14-3-6-16(7-4-14)30-12-19-17(22(30)31)9-10-29-21(19)18-8-5-15(25)11-20(18)33-13-24(26,27)28/h3-11,32H,12-13H2,1-2H3 |
| InChIKey | OAZAPIKYVGRNCO-UHFFFAOYSA-N |
| SMILES | CC(C)(C1=CC=C(C=C1)N2CC3=C(C2=O)C=CN=C3C4=C(C=C(C=C4)F)OCC(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
