For research use only. Not for therapeutic Use.
TP-004(CAT: I017419) is a potent and reversible methionine aminopeptidase 2 (MetAP2) inhibitor with an IC50 of 6 nM. By selectively blocking MetAP2 activity, TP-004 interferes with the removal of N-terminal methionine residues during protein maturation, a process critical for protein stability and function. MetAP2 inhibition has been linked to the regulation of angiogenesis, tumor growth, and metabolic pathways, making TP-004 a valuable tool for exploring therapeutic strategies in oncology, inflammation, and metabolic disease research. Its high potency and reversibility highlight TP-004’s utility in dissecting MetAP2-mediated cellular mechanisms and advancing drug discovery programs targeting protein processing enzymes.
| CAS Number | 1454299-21-8 |
| Synonyms | (3R)-1-[4-methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]pyrimidin-2-yl]pyrrolidin-3-ol |
| Molecular Formula | C17H16F3N5O |
| Purity | ≥95% |
| IUPAC Name | (3R)-1-[4-methyl-5-[6-(trifluoromethyl)-1H-indazol-4-yl]pyrimidin-2-yl]pyrrolidin-3-ol |
| InChI | InChI=1S/C17H16F3N5O/c1-9-13(6-21-16(23-9)25-3-2-11(26)8-25)12-4-10(17(18,19)20)5-15-14(12)7-22-24-15/h4-7,11,26H,2-3,8H2,1H3,(H,22,24)/t11-/m1/s1 |
| InChIKey | BNTAEJNPQLMGDJ-LLVKDONJSA-N |
| SMILES | CC1=NC(=NC=C1C2=C3C=NNC3=CC(=C2)C(F)(F)F)N4CCC(C4)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
