For research use only. Not for therapeutic Use.
Tos-PEG2-THP (Cat No.: I045417) is a heterobifunctional polyethylene glycol (PEG) linker composed of two ethylene glycol units for enhanced solubility, flexibility, and reduced steric hindrance. It carries a tosyl (p-toluenesulfonyl) group, a strong electrophile for nucleophilic substitution, and a tetrahydropyranyl (THP) group that serves as an acid-labile protecting group for hydroxyl functionalities. The PEG2 spacer improves hydrophilicity and facilitates reactions in both aqueous and organic media. Tos-PEG2-THP is commonly used in bioconjugation, organic synthesis, and surface or polymer functionalization in chemical and biomedical research.
| CAS Number | 69502-32-5 |
| Synonyms | 2-[2-(oxan-2-yloxy)ethoxy]ethyl 4-methylbenzenesulfonate |
| Molecular Formula | C16H24O6S |
| Purity | ≥95% |
| InChI | InChI=1S/C16H24O6S/c1-14-5-7-15(8-6-14)23(17,18)22-13-11-19-10-12-21-16-4-2-3-9-20-16/h5-8,16H,2-4,9-13H2,1H3 |
| InChIKey | MYIMMUFXKWKAID-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOC2CCCCO2 |
| Reference | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
