For research use only. Not for therapeutic Use.
Topiramate D12 (CAT: R005550) is a stable isotope-labeled form of Topiramate, a broad-spectrum antiepileptic drug (AED) widely used in the treatment of epilepsy and related neurological disorders. Incorporating twelve deuterium atoms, it serves as an internal standard for LC-MS/MS quantification in pharmacokinetic, metabolism, and bioanalytical studies. Topiramate exerts antiepileptic effects via multiple mechanisms, including enhancement of GABAergic transmission, inhibition of kainate/AMPA receptors, blockade of voltage-gated sodium and calcium channels, increased potassium conductance, and inhibition of carbonic anhydrase. Topiramate D12 is a valuable tool for drug metabolism, pharmacology, and neuroscience research, enabling precise analytical measurements.
| CAS Number | 1279037-95-4 |
| Synonyms | [(1R,2S,6S,9R)-4,4,11,11-tetrakis(trideuteriomethyl)-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate |
| Molecular Formula | C12H9D12NO8S |
| Purity | ≥95% |
| IUPAC Name | [(1R,2S,6S,9R)-4,4,11,11-tetrakis(trideuteriomethyl)-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate |
| InChI | InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1/i1D3,2D3,3D3,4D3 |
| InChIKey | KJADKKWYZYXHBB-RFYKXYJISA-N |
| SMILES | CC1(OC2COC3(C(C2O1)OC(O3)(C)C)COS(=O)(=O)N)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
