Tolcapone-d4

• CAT Number: R046736
• CAS Number: 1246816-93-2
• Molecular Formula: C14H7D4NO5
• Molecular Weight: 277.27
• Purity: ≥95%
• Synonyms: (3,4-dihydroxy-5-nitrophenyl)-(2,3,5,6-tetradeuterio-4-methylphenyl)methanone
• InChI: InChI=1S/C14H11NO5/c1-8-2-4-9(5-3-8)13(17)10-6-11(15(19)20)14(18)12(16)7-10/h2-7,16,18H,1H3/i2D,3D,4D,5D
• InChIKey: MIQPIUSUKVNLNT-QFFDRWTDSA-N
• SMILES: [2H]C1=C(C(=C(C(=C1C)[2H])[2H])C(=O)C2=CC(=C(C(=C2)O)O)[N+](=O)[O-])[2H]

Tolcapone-d₄（Cat No.:R046736）is a deuterated form of tolcapone, a selective and reversible inhibitor of catechol-O-methyltransferase (COMT), an enzyme involved in the metabolism of dopamine. By replacing four hydrogen atoms with deuterium, Tolcapone-d₄ is ideal as an internal standard in LC-MS/MS assays for accurate quantification of tolcapone in biological samples. It retains the same pharmacological activity, making it useful in pharmacokinetic, bioavailability, and drug metabolism studies related to Parkinson’s disease. Tolcapone-d₄ is intended for research and analytical use only; not for therapeutic, diagnostic, or veterinary applications.