For research use only. Not for therapeutic Use.
TNIK-IN-1(CAT: I037373) is a potent and selective inhibitor of Traf2- and Nck-interacting kinase (TNIK), a serine/threonine kinase involved in Wnt/β-catenin signaling and cytoskeletal regulation. By targeting TNIK, TNIK-IN-1 disrupts TCF4-mediated transcription and downstream oncogenic pathways, making it a valuable compound in cancer research—particularly in colorectal and gastric cancers where TNIK is upregulated. This small-molecule inhibitor is useful for studying kinase function, signal transduction, and the modulation of gene expression related to cell proliferation and migration. TNIK-IN-1 supports both in vitro and in vivo applications in pharmacological and mechanistic studies.
| CAS Number | 933886-36-3 |
| Synonyms | 5-[(4-acetamidobenzoyl)amino]-2-anilino-1,3-thiazole-4-carboxamide |
| Molecular Formula | C19H17N5O3S |
| Purity | ≥95% |
| IUPAC Name | 5-[(4-acetamidobenzoyl)amino]-2-anilino-1,3-thiazole-4-carboxamide |
| InChI | InChI=1S/C19H17N5O3S/c1-11(25)21-14-9-7-12(8-10-14)17(27)24-18-15(16(20)26)23-19(28-18)22-13-5-3-2-4-6-13/h2-10H,1H3,(H2,20,26)(H,21,25)(H,22,23)(H,24,27) |
| InChIKey | OOYMGIRITPQNDA-UHFFFAOYSA-N |
| SMILES | CC(=O)NC1=CC=C(C=C1)C(=O)NC2=C(N=C(S2)NC3=CC=CC=C3)C(=O)N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
