TMX-4113

• CAT Number: I045151
• CAS Number: 2766385-92-4
• Molecular Formula: C12H12N4O2S2
• Molecular Weight: 308.38
• Purity: ≥95%
• Synonyms: 3-[4-(4-methylsulfanylthiophen-3-yl)triazol-1-yl]piperidine-2,6-dione
• InChI: InChI=1S/C12H12N4O2S2/c1-19-10-6-20-5-7(10)8-4-16(15-14-8)9-2-3-11(17)13-12(9)18/h4-6,9H,2-3H2,1H3,(H,13,17,18)
• InChIKey: YIIUEHDPOPLUBR-UHFFFAOYSA-N
• SMILES: CSC1=CSC=C1C2=CN(N=N2)C3CCC(=O)NC3=O

TMX-4113（Cat No.:I045151）is a dual degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α), designed as a chemical probe for cancer research. In MOLT4 cells, 1 µM TMX-4113 (4-hour exposure) effectively degrades both targets, and in MM.1S cells, it causes more than 50% CK1α degradation at just 40 nM. It has a molecular weight of 308.38 Da with formula C₁₂H₁₂N₄O₂S₂. TMX-4113 serves as a valuable dual-target degrader for probing PDE6D/CK1α pathways in cancer biology.