TMP780

• CAT Number: I017497
• CAS Number: 1422053-03-9
• Molecular Formula: C31H30N2O4
• Molecular Weight: 494.58
• Purity: ≥95%
• Synonyms: 2-[2-[(R)-(3,5-dimethyl-1,2-oxazol-4-yl)-hydroxymethyl]-1-benzofuran-5-yl]-N-[(S)-(2,4-dimethylphenyl)-phenylmethyl]acetamide
• InChI: InChI=1S/C31H30N2O4/c1-18-10-12-25(19(2)14-18)30(23-8-6-5-7-9-23)32-28(34)16-22-11-13-26-24(15-22)17-27(36-26)31(35)29-20(3)33-37-21(29)4/h5-15,17,30-31,35H,16H2,1-4H3,(H,32,34)/t30-,31-/m0/s1
• InChIKey: DIURRJOJDQOMFC-CONSDPRKSA-N
• SMILES: CC1=CC(=C(C=C1)C(C2=CC=CC=C2)NC(=O)CC3=CC4=C(C=C3)OC(=C4)C(C5=C(ON=C5C)C)O)C

TMP780(CAT: I017497) is a potent inverse agonist of the nuclear receptor RORγt, with an IC₅₀ of 13 nM. By selectively targeting RORγt, TMP780 suppresses transcriptional activity associated with Th17 cell differentiation and IL-17 production, pathways critically involved in autoimmune and inflammatory disorders. Preclinical studies suggest that modulation of RORγt with TMP780 holds therapeutic promise for cutaneous inflammatory conditions, including psoriasis and related skin diseases. Its high potency and mechanism of action make it a valuable pharmacological tool for exploring RORγt biology, immune regulation, and the development of next-generation therapeutics for inflammatory and autoimmune diseases.