For research use only. Not for therapeutic Use.
TLX Agonist 1 (CAT: I017309) is a selective orphan nuclear receptor TLX (NR2E1) modulator with an EC50 of 1 μM and a binding affinity (Kd) of 650 nM. By enhancing TLX transcriptional repressive activity, it provides a unique tool for investigating the role of TLX in neural stem cell maintenance, neurogenesis, and brain development. TLX is also implicated in oncogenesis and metabolic regulation, making TLX Agonist 1 valuable for both neuroscience and cancer research. As one of the few available small-molecule modulators of TLX, it supports studies in nuclear receptor biology, epigenetic regulation, and CNS therapeutics.
| CAS Number | 958323-31-4 |
| Synonyms | (4-benzhydrylpiperazin-1-yl)-(1,5-dimethylpyrazol-3-yl)methanone |
| Molecular Formula | C23H26N4O |
| Purity | ≥95% |
| IUPAC Name | (4-benzhydrylpiperazin-1-yl)-(1,5-dimethylpyrazol-3-yl)methanone |
| InChI | InChI=1S/C23H26N4O/c1-18-17-21(24-25(18)2)23(28)27-15-13-26(14-16-27)22(19-9-5-3-6-10-19)20-11-7-4-8-12-20/h3-12,17,22H,13-16H2,1-2H3 |
| InChIKey | SSGJAUSSGPIZEE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=NN1C)C(=O)N2CCN(CC2)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
