For research use only. Not for therapeutic Use.
TLR7/8-IN-1（Cat No.:I044419）is a selective small-molecule inhibitor targeting Toll-like receptors 7 and 8 (TLR7/8), which play critical roles in innate immune activation by recognizing single-stranded RNA. By blocking TLR7/8 signaling, this compound suppresses the production of pro-inflammatory cytokines such as TNF-α, IL-6, and IFN-α, thereby modulating immune responses. TLR7/8-IN-1 is valuable in research focused on autoimmune and inflammatory diseases, including lupus and rheumatoid arthritis, where TLR-driven immune dysregulation is implicated. Its selective inhibition aids in dissecting the roles of TLR7 and TLR8 in disease models and therapeutic development.
| CAS Number | 2205095-75-4 |
| Synonyms | (3S)-N-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide |
| Molecular Formula | C29H40N8O2 |
| Purity | ≥95% |
| IUPAC Name | (3S)-N-[4-[[5-(1,6-dimethylpyrazolo[3,4-b]pyridin-4-yl)-3-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]methyl]-1-bicyclo[2.2.2]octanyl]morpholine-3-carboxamide |
| InChI | InChI=1S/C29H40N8O2/c1-19-14-25(21-15-31-35(3)26(21)32-19)36-12-4-24-22(16-36)20(2)34-37(24)18-28-5-8-29(9-6-28,10-7-28)33-27(38)23-17-39-13-11-30-23/h14-15,23,30H,4-13,16-18H2,1-3H3,(H,33,38)/t23-,28?,29?/m0/s1 |
| InChIKey | OXDQXRVWDYGAHX-SAVAPUMLSA-N |
| SMILES | CC1=CC(=C2C=NN(C2=N1)C)N3CCC4=C(C3)C(=NN4CC56CCC(CC5)(CC6)NC(=O)[C@@H]7COCCN7)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
