For research use only. Not for therapeutic Use.
TLR7/8 Antagonist 2（Cat No.:I044046）is a selective small-molecule inhibitor that targets Toll-like receptors 7 and 8 (TLR7/8), key mediators of innate immune signaling involved in recognizing single-stranded RNA. By blocking TLR7/8 activation, this antagonist reduces downstream pro-inflammatory cytokine production, including TNF-α and IFN-α, making it valuable for studying autoimmune and inflammatory diseases such as lupus and psoriasis. TLR7/8 Antagonist 2 offers a strategic approach to modulate overactive immune responses, supporting research into immune regulation, cytokine signaling, and the development of anti-inflammatory therapies with improved specificity and reduced systemic immune activation.
| CAS Number | 2769085-03-0 |
| Synonyms | 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-[(3S,4S)-3-fluoropiperidin-4-yl]-1H-indazol-3-amine |
| Molecular Formula | C22H26FN5 |
| Purity | ≥95% |
| IUPAC Name | 5-cyclopropyl-6-(2,6-dimethylpyridin-4-yl)-N-[(3S,4S)-3-fluoropiperidin-4-yl]-1H-indazol-3-amine |
| InChI | InChI=1S/C22H26FN5/c1-12-7-15(8-13(2)25-12)17-10-21-18(9-16(17)14-3-4-14)22(28-27-21)26-20-5-6-24-11-19(20)23/h7-10,14,19-20,24H,3-6,11H2,1-2H3,(H2,26,27,28)/t19-,20-/m0/s1 |
| InChIKey | JUSJRQVEHUHMRQ-PMACEKPBSA-N |
| SMILES | CC1=CC(=CC(=N1)C)C2=C(C=C3C(=C2)NN=C3N[C@H]4CCNC[C@@H]4F)C5CC5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
