TLR7/8/9-IN-1

• CAT Number: I045433
• CAS Number: 2180127-82-4
• Molecular Formula: C27H37N3O2
• Molecular Weight: 435.60
• Purity: ≥95%
• Synonyms: 2-[4-[2-(3,4-dimethoxyphenyl)-3-propan-2-yl-1H-indol-5-yl]piperidin-1-yl]-N-methylethanamine
• InChI: InChI=1S/C27H37N3O2/c1-18(2)26-22-16-20(19-10-13-30(14-11-19)15-12-28-3)6-8-23(22)29-27(26)21-7-9-24(31-4)25(17-21)32-5/h6-9,16-19,28-29H,10-15H2,1-5H3
• InChIKey: UKYUETHIPBXYBQ-UHFFFAOYSA-N
• SMILES: CC(C)C1=C(NC2=C1C=C(C=C2)C3CCN(CC3)CCNC)C4=CC(=C(C=C4)OC)OC

TLR7/8/9-IN-1 (Cat No.: I045433) is a potent, selective small-molecule inhibitor of Toll-like receptors 7, 8, and 9, key pattern recognition receptors involved in innate immune activation through nucleic acid sensing. By blocking these receptors’ signaling pathways, it suppresses downstream production of pro-inflammatory cytokines and type I interferons. This compound is used in research to investigate TLR-mediated immune responses and their roles in autoimmune and inflammatory diseases such as lupus, psoriasis, and rheumatoid arthritis, offering potential for therapeutic development targeting dysregulated innate immunity.

Reference

[1]. Mussari CP, et al. Discovery of Potent and Orally Bioavailable Small Molecule Antagonists of Toll-like Receptors 7/8/9 (TLR7/8/9). ACS Med Chem Lett. 2020 Jul 29;11(9):1751-1758.
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