For research use only. Not for therapeutic Use.
TL13-12(CAT: I016421) is a potent and selective ALK-PROTAC degrader with an IC₅₀ of 0.69 nM for ALK inhibition. Constructed through the conjugation of TAE684 (HY-10192) and the Cereblon (CRBN) ligand of Pomalidomide (HY-10984), it leverages targeted protein degradation to suppress ALK-driven signaling. Beyond ALK, TL13-12 induces degradation of additional kinases, including Aurora A (IC₅₀ = 13.5 nM), FER (5.74 nM), PTK2 (18.4 nM), and RPS6KA1 (65 nM). This dual mechanism—direct kinase inhibition and proteasomal degradation—makes TL13-12 a valuable research tool for studying ALK-driven cancers and advancing PROTAC-based therapeutic strategies in oncology.
| CAS Number | 2229037-04-9 |
| Synonyms | N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| Molecular Formula | C45H53ClN10O10S |
| Purity | ≥95% |
| IUPAC Name | N-[2-[2-[2-[4-[4-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]-3-methoxyphenyl]piperazin-1-yl]ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-4-yl]amino]acetamide |
| InChI | InChI=1S/C45H53ClN10O10S/c1-28(2)67(62,63)37-10-5-4-8-33(37)50-41-31(46)26-49-45(53-41)51-32-12-11-29(25-36(32)64-3)55-18-16-54(17-19-55)20-22-66-24-23-65-21-15-47-39(58)27-48-34-9-6-7-30-40(34)44(61)56(43(30)60)35-13-14-38(57)52-42(35)59/h4-12,25-26,28,35,48H,13-24,27H2,1-3H3,(H,47,58)(H,52,57,59)(H2,49,50,51,53) |
| InChIKey | WXNUIPVZMJMPNM-UHFFFAOYSA-N |
| SMILES | CC(C)S(=O)(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCN(CC4)CCOCCOCCNC(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)OC |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
