For research use only. Not for therapeutic Use.
TL-895（Cat No.:I044395）is a potent, selective, orally bioavailable inhibitor of Bruton’s tyrosine kinase (BTK) and bone marrow tyrosine kinase on chromosome X (BMX), key regulators of B-cell receptor signaling and inflammatory pathways. It is being developed for the treatment of hematologic malignancies such as chronic lymphocytic leukemia (CLL) and myelofibrosis. TL-895 disrupts survival signals in malignant B cells and modulates the tumor microenvironment, showing promising activity in patients resistant or intolerant to other BTK inhibitors. With favorable pharmacokinetics and tolerability, TL-895 represents a next-generation therapeutic option in targeted cancer therapy.
| CAS Number | 1415823-49-2 |
| Synonyms | 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]-4-fluoropiperidin-1-yl]prop-2-en-1-one |
| Molecular Formula | C25H26FN5O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-[[[6-amino-5-(4-phenoxyphenyl)pyrimidin-4-yl]amino]methyl]-4-fluoropiperidin-1-yl]prop-2-en-1-one |
| InChI | InChI=1S/C25H26FN5O2/c1-2-21(32)31-14-12-25(26,13-15-31)16-28-24-22(23(27)29-17-30-24)18-8-10-20(11-9-18)33-19-6-4-3-5-7-19/h2-11,17H,1,12-16H2,(H3,27,28,29,30) |
| InChIKey | OXOXFDSEGFLWLU-UHFFFAOYSA-N |
| SMILES | C=CC(=O)N1CCC(CC1)(CNC2=NC=NC(=C2C3=CC=C(C=C3)OC4=CC=CC=C4)N)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
