(-)-TK216

• CAT Number: I045510
• CAS Number: 1903783-78-7
• Molecular Formula: C19H15Cl2NO3
• Molecular Weight: 376.23
• Purity: ≥95%

(−)-TK216 (Cat No.: I045510) is the enantiomer of TK216, developed as a structural counterpart in the study of EWS-FLI1–driven oncogenesis. Unlike its active (+) form, (−)-TK216 serves primarily as a reference compound in stereochemical and pharmacological investigations. Researchers employ it to assess enantiomer-specific activity, binding selectivity, and off-target effects in Ewing sarcoma models and other fusion-driven cancers. Its use provides critical insights into chirality-dependent drug action, helping to validate the therapeutic relevance and specificity of TK216 in oncology research.

Reference

[1]. Spriano F, et al. The ETS Inhibitors YK-4-279 and TK-216 Are Novel Antilymphoma Agents. Clin Cancer Res. 2019 Aug 15;25(16):5167-5176.
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[2]. Jean-Michael Vernier, et al. Indolinone compounds and uses thereof. WO2016057698A1.