For research use only. Not for therapeutic Use.
Tiotidine(CAT: I010307) is a selective histamine H₂ receptor antagonist that inhibits gastric acid secretion by competitively blocking histamine action on parietal cells. Structurally related to cimetidine, Tiotidine exhibits high potency and selectivity for H₂ receptors with minimal effects on H₁ and H₃ subtypes. It effectively reduces basal and stimulated gastric acid output, making it a key research compound for studying gastric physiology, acid-related disorders, and H₂ receptor pharmacology. Tiotidine is widely used in experimental models to investigate histamine-mediated signaling, ulcer pathogenesis, and the mechanistic evaluation of gastroprotective agents.
| CAS Number | 69014-14-8 |
| Synonyms | 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine |
| Molecular Formula | C10H16N8S2 |
| Purity | ≥95% |
| IUPAC Name | 1-cyano-3-[2-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]ethyl]-2-methylguanidine |
| InChI | InChI=1S/C10H16N8S2/c1-14-9(16-6-11)15-2-3-19-4-7-5-20-10(17-7)18-8(12)13/h5H,2-4H2,1H3,(H2,14,15,16)(H4,12,13,17,18) |
| InChIKey | YDDXVAXDYKBWDX-UHFFFAOYSA-N |
| SMILES | CN=C(NCCSCC1=CSC(=N1)N=C(N)N)NC#N |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
