Tigogenin

• CAT Number: R026009
• CAS Number: 77-60-1
• Molecular Formula: C27H44O3
• Molecular Weight: 416.64
• Purity: ≥95%
• Synonyms: (1R,2S,4S,5’R,6R,7S,8R,9S,12S,13S,16S,18S)-5′,7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2′-oxane]-16-ol
• IUPAC Name: (1R,2S,4S,5'R,6R,7S,8R,9S,12S,13S,16S,18S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icosane-6,2'-oxane]-16-ol
• InChI: InChI=1S/C27H44O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h16-24,28H,5-15H2,1-4H3/t16-,17+,18+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1
• InChIKey: GMBQZIIUCVWOCD-MFRNJXNGSA-N
• SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)OC1

Tigogenin(CAT:R026009) is a spirostan-type steroidal sapogenin commonly derived from plants such as Agave and Dioscorea species. It serves as a key aglycone backbone of various steroidal saponins and has attracted interest in both pharmacology and synthetic chemistry. Studies report that Tigogenin exhibits anti-inflammatory, anticancer, hypoglycemic, and cholesterol-lowering effects, partly through modulation of metabolic and immune-related pathways. It has also been investigated for its protective roles in cardiovascular and hepatic health. Beyond its direct bioactivities, Tigogenin is an important precursor in the semisynthesis of steroidal drugs, including corticosteroids and contraceptives. With this dual relevance, Tigogenin is valued in drug discovery, natural product chemistry, and therapeutic research.