For research use only. Not for therapeutic Use.
TIE-2/VEGFR-2 kinase-IN-2（Cat No.:I044353）is a dual kinase inhibitor targeting the TIE-2 and VEGFR-2 receptors, both of which play critical roles in angiogenesis and vascular stability. By simultaneously blocking these kinases, the compound disrupts endothelial cell signaling, reducing new blood vessel formation and vascular permeability—processes vital for tumor growth and metastasis. TIE-2/VEGFR-2 kinase-IN-2 is primarily investigated for its anti-angiogenic potential in cancer therapy and ocular diseases such as age-related macular degeneration. Its dual-target approach offers enhanced efficacy in modulating pathological angiogenesis compared to single-target inhibitors.
| CAS Number | 501693-48-7 |
| Synonyms | 1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| Molecular Formula | C20H13F4N5O2 |
| Purity | ≥95% |
| IUPAC Name | 1-[4-(4-aminofuro[2,3-d]pyrimidin-5-yl)phenyl]-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea |
| InChI | InChI=1S/C20H13F4N5O2/c21-14-6-3-11(20(22,23)24)7-15(14)29-19(30)28-12-4-1-10(2-5-12)13-8-31-18-16(13)17(25)26-9-27-18/h1-9H,(H2,25,26,27)(H2,28,29,30) |
| InChIKey | KNDPXYAMINMLED-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC=C1C2=COC3=NC=NC(=C23)N)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
