TIE-2/VEGFR-2 kinase-IN-1

• CAT Number: I015379
• CAS Number: 453590-24-4
• Molecular Formula: C13H11N3O2
• Molecular Weight: 241.25
• Purity: ≥95%
• Synonyms: 6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine
• InChI: InChI=1S/C13H11N3O2/c1-17-9-4-2-8(3-5-9)11-6-10-12(14)15-7-16-13(10)18-11/h2-7H,1H3,(H2,14,15,16)
• InChIKey: DIJLFIHLUYAZCI-UHFFFAOYSA-N
• SMILES: COC1=CC=C(C=C1)C2=CC3=C(N=CN=C3O2)N

TIE-2/VEGFR-2 kinase-IN-1（Cat No.:I015379）is a potent dual inhibitor targeting TIE-2 and VEGFR-2 receptor tyrosine kinases, both crucial regulators of angiogenesis and vascular remodeling. By simultaneously blocking these kinases, it disrupts endothelial cell signaling, reducing abnormal blood vessel formation and tumor vascularization. This compound is particularly useful in cancer research, enabling studies on anti-angiogenic strategies and tumor microenvironment modulation. Its dual-target activity makes it a valuable tool for investigating synergistic pathways in vascular biology and developing therapeutic approaches against angiogenesis-driven diseases.