Tiamulin

• CAT Number: R063031
• CAS Number: 55297-95-5
• Molecular Formula: C28H47NO4S
• Molecular Weight: 493.74
• Purity: ≥95%
• Synonyms: [(1S,2R,3S,4S,6R,7R,8R,14R)-4-ethenyl-3-hydroxy-2,4,7,14-tetramethyl-9-oxo-6-tricyclo[5.4.3.01,8]tetradecanyl] 2-[2-(diethylamino)ethylsulfanyl]acetate
• InChI: InChI=1S/C28H47NO4S/c1-8-26(6)17-22(33-23(31)18-34-16-15-29(9-2)10-3)27(7)19(4)11-13-28(20(5)25(26)32)14-12-21(30)24(27)28/h8,19-20,22,24-25,32H,1,9-18H2,2-7H3/t19-,20+,22-,24+,25+,26-,27+,28+/m1/s1
• InChIKey: UURAUHCOJAIIRQ-QGLSALSOSA-N
• SMILES: CCN(CC)CCSCC(=O)OC1CC(C(C(C23CCC(C1(C2C(=O)CC3)C)C)C)O)(C)C=C

Tiamulin(CAT: R063031) is a semi-synthetic pleuromutilin antibiotic widely used in veterinary medicine, particularly for swine and poultry. It acts by binding to the 50S ribosomal subunit, inhibiting protein synthesis in susceptible bacteria. Tiamulin demonstrates strong activity against Gram-positive organisms and mycoplasmas, making it effective for treating swine dysentery (Brachyspira hyodysenteriae), enzootic pneumonia (Mycoplasma hyopneumoniae), and other respiratory or enteric infections. With excellent oral bioavailability and tissue penetration, Tiamulin is a preferred agent for controlling bacterial and mycoplasmal diseases in livestock. It is also a valuable research tool in studying ribosome-targeting antibiotics, antimicrobial resistance, and pleuromutilin derivatives.