For research use only. Not for therapeutic Use.
The black seeds of <em>Nigella</em> have long been ingested to treat a broad range of diseases, including inflammation and cancer. Thymoquinone is a natural phytochemical isolated from the seeds of <em>N. sativa</em>. It has anti-<wbr></wbr>inflammatory effects, blocking the synthesis of leukotrienes. Thymoquinone inhibits the growth of leukemia cells (IC<sub>50</sub> = 1.5 μg/ml), inducing apoptosis by down-<wbr></wbr>regulating the expression of Bcl-<wbr></wbr>2 while up-<wbr></wbr>regulating Bax expression. In addition to blocking cell proliferation and triggering apoptosis, thymoquinone (15 μM) suppresses STAT3-<wbr></wbr>regulated gene expression and prevents angiogenesis.
| CAS Number | 490-91-5 |
| Synonyms | 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione; p-Mentha-3,6-?diene-2,5-dione; 2-Isopropyl-5-methyl-1,4-benzoquinone; 2-Isopropyl-5-methyl-p-benzoquinone; 2-Isopropyl-5-methylbenzoquinone; 2-Methyl-5-isopropyl-1,4-benzoquinone; 2-Methyl-5-is |
| Molecular Formula | C10H12O2 |
| Purity | ≥95% |
| Target | Protein Tyrosine Kinase/RTK |
| Storage | -20°C |
| IUPAC Name | 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione |
| InChI | InChI=1S/C10H12O2/c1-6(2)8-5-9(11)7(3)4-10(8)12/h4-6H,1-3H3 |
| InChIKey | KEQHJBNSCLWCAE-UHFFFAOYSA-N |
| SMILES | CC1=CC(=O)C(=CC1=O)C(C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
