THP-PEG4-Pyrrolidine(N-Me)-CH2OH

• CAT Number: I016931
• CAS Number: 2378261-81-3
• Molecular Formula: C19H37NO7
• Molecular Weight: 391.50
• Purity: ≥95%
• Synonyms: [(2S,4R)-1-methyl-4-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]pyrrolidin-2-yl]methanol
• InChI: InChI=1S/C19H37NO7/c1-20-15-18(14-17(20)16-21)25-12-10-23-8-6-22-7-9-24-11-13-27-19-4-2-3-5-26-19/h17-19,21H,2-16H2,1H3/t17-,18+,19?/m0/s1
• InChIKey: WSIXZTYJDDDXDX-PAMZHZACSA-N
• SMILES: CN1CC(CC1CO)OCCOCCOCCOCCOC2CCCCO2

THP-PEG4-Pyrrolidine(N-Me)-CH₂OH(CAT: I016931) is a heterobifunctional polyethylene glycol (PEG) linker designed for advanced chemical biology and drug discovery applications. It incorporates a THP (tetrahydropyranyl)-protected hydroxyl group, a PEG4 spacer for hydrophilicity and flexibility, and a N-methylated pyrrolidine moiety terminating with a hydroxymethyl group. This unique structure provides multiple functional handles, enabling sequential deprotection and selective conjugation strategies. The PEG4 backbone reduces steric hindrance, enhances solubility, and improves biocompatibility, making it suitable for PROTAC development, targeted delivery systems, and surface functionalization. THP-PEG4-Pyrrolidine(N-Me)-CH₂OH is an ideal building block for assembling multifunctional molecular architectures in medicinal chemistry and bioconjugation research.