THP-PEG4-Pyrrolidine(N-Boc)-CH2OH

• CAT Number: I016932
• CAS Number: 2378261-80-2
• Molecular Formula: C23H43NO9
• Molecular Weight: 477.59
• Purity: ≥95%
• Synonyms: tert-butyl (2S,4R)-2-(hydroxymethyl)-4-[2-[2-[2-[2-(oxan-2-yloxy)ethoxy]ethoxy]ethoxy]ethoxy]pyrrolidine-1-carboxylate
• InChI: InChI=1S/C23H43NO9/c1-23(2,3)33-22(26)24-17-20(16-19(24)18-25)30-14-12-28-10-8-27-9-11-29-13-15-32-21-6-4-5-7-31-21/h19-21,25H,4-18H2,1-3H3/t19-,20+,21?/m0/s1
• InChIKey: ZKEBNPQGNDNRDY-MCOCGALXSA-N
• SMILES: CC(C)(C)OC(=O)N1CC(CC1CO)OCCOCCOCCOCCOC2CCCCO2

THP-PEG4-Pyrrolidine(N-Boc)-CH₂OH(CAT: I016932) is a multifunctional polyethylene glycol (PEG) linker designed for use in bioconjugation and medicinal chemistry. It features a tetrahydropyranyl (THP)-protected hydroxyl group, a PEG4 spacer that enhances solubility and flexibility, and a pyrrolidine moiety protected with a Boc group, allowing controlled deprotection and selective downstream coupling. The terminal hydroxymethyl group provides an additional reactive site for further functionalization. With orthogonal protection and excellent aqueous compatibility, this reagent is particularly suited for the synthesis of PROTACs, drug conjugates, and biomolecular probes, enabling precise assembly of complex molecular architectures in chemical biology and therapeutic development.