THIOCHOLINE IODIDE

• CAT Number: M000190
• CAS Number: 7161-73-1
• Molecular Formula: C5H14INS
• Molecular Weight: 247.14
• Purity: ≥95%
• Synonyms: THIOCHOLINE IODIDE;(2-mercaptoethyl)trimethylammonium iodide;ThiocholineIodide,~97%;Trimethyl(2-mercaptoethyl)aminium·iodide;EthanaMiniuM, 2-Mercapto-N,N,N-triMethyl-, iodide;EthanaMiniuM,2-Mercapto-N,N,N-triMethyl-, iodide (1:1)
• Storage: RT
• IUPAC Name: trimethyl(2-sulfanylethyl)azanium;iodide
• InChI: InChI=1S/C5H13NS.HI/c1-6(2,3)4-5-7;/h4-5H2,1-3H3;1H
• InChIKey: CTGNYPVJSIRPLG-UHFFFAOYSA-N
• SMILES: C[N+](C)(C)CCS.[I-]

Thiocholine iodide（Cat No.:M000190）, is a chemical compound primarily used in biochemical and pharmacological research. It is a quaternary ammonium compound and an iodide salt derivative of thiocholine, a metabolite of acetylcholine. Thiocholine iodide is often used as a substrate in enzymatic assays to measure the activity of acetylcholinesterase (AChE), an enzyme that plays a vital role in neurotransmission. Studying AChE activity is important in understanding nervous system function and the mechanisms of action of drugs and toxins. Thiocholine iodide’s biochemical properties make it a valuable tool in neurochemistry and toxicology research.

Reference

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activity by means of the electron dense precipitate derived from Koelle/’s cuprous
thiocholine iodide by treatment with phosphomolybdic acid and osmium tetroxide.
Histochemistry. 1984;80(1):19-21. PubMed PMID: 6698812.

2: Tsuji S, Larabi Y. A modification of thiocholine-ferricyanide method of
Karnovsky and Roots for localization of acetylcholinesterase activity without
interference by Koelle/’s copper thiocholine iodide precipitate. Histochemistry.
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3: Wustner DA, Sanborn JR. A facile synthesis of esters of thiocholine iodide,
substrates for cholinesterase. J Econ Entomol. 1972 Dec;65(6):1745. PubMed PMID:
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4: Hussain A, Schurman P. Thiol esters. II. A kinetic study of hydrolysis and
aminolysis of propionyl thiocholine iodide and 2-dimethylaminoethanethiol
propionate. J Pharm Sci. 1969 Jun;58(6):687-93. PubMed PMID: 5799755.

5: GUILBAULT GG, KRAMER DN, CANNON PL Jr. A new, general electrochemical method
of determining enzyme kinetics. Kinetics of the enzymic hydrolysis of thiocholine
iodide esters. Anal Biochem. 1963 Mar;5:208-16. PubMed PMID: 13951223.