Thiamine pyrophosphate-d3

• CAT Number: I044129
• CAS Number: 2483831-79-2
• Molecular Formula: C12H16D3ClN4O7P2S
• Molecular Weight: 463.79
• Purity: ≥95%
• Synonyms: 2-[3-[[4-amino-2-(trideuteriomethyl)pyrimidin-5-yl]methyl]-4-methyl-1,3-thiazol-3-ium-5-yl]ethyl phosphono hydrogen phosphate;chloride
• InChI: InChI=1S/C12H18N4O7P2S.ClH/c1-8-11(3-4-22-25(20,21)23-24(17,18)19)26-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7H,3-4,6H2,1-2H3,(H4-,13,14,15,17,18,19,20,21);1H/i2D3
• InChIKey: YXVCLPJQTZXJLH-MUTAZJQDSA-N
• SMILES: [2H]C([2H])([2H])C1=NC=C(C(=N1)N)C[N+]2=CSC(=C2C)CCOP(=O)(O)OP(=O)(O)O.[Cl-]

Thiamine pyrophosphate-d3 (Cat No.:I044129) is a stable isotope-labeled analog of thiamine pyrophosphate, with three deuterium atoms incorporated for use in mass spectrometry-based analytical applications. As the active coenzyme form of vitamin B1, TPP is essential for enzymatic reactions involved in carbohydrate metabolism, including pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, and transketolase activity. TPP-d3 is primarily used as an internal standard for accurate quantification of thiamine derivatives in biological samples. It enables precise metabolic profiling and supports research into nutritional status, mitochondrial function, and disorders related to thiamine deficiency.