Thalidomide-Propargyne-PEG1-COOH

• CAT Number: I044483
• CAS Number: 2828438-36-2
• Molecular Formula: C19H16N2O7
• Molecular Weight: 384.34
• Purity: ≥95%
• Synonyms: 3-[3-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]prop-2-ynoxy]propanoic acid
• InChI: InChI=1S/C19H16N2O7/c22-15-6-5-14(17(25)20-15)21-18(26)12-4-3-11(10-13(12)19(21)27)2-1-8-28-9-7-16(23)24/h3-4,10,14H,5-9H2,(H,23,24)(H,20,22,25)
• InChIKey: HVNLXJHGBVADJO-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)C#CCOCCC(=O)O

Thalidomide-Propargyne-PEG1-COOH（Cat No.:I044483）is a specialized bifunctional linker used in targeted protein degradation and chemical biology applications. It features a thalidomide moiety for cereblon E3 ligase recruitment, a propargyl (alkyne) group for bioorthogonal click chemistry, and a PEG1 (monoethylene glycol) spacer that improves solubility and flexibility. The terminal carboxylic acid group allows for conjugation to amine-functionalized molecules. This linker design enables precise assembly of PROTACs or other molecular probes, facilitating efficient and selective degradation of target proteins while enhancing pharmacokinetic properties through improved aqueous compatibility.