For research use only. Not for therapeutic Use.
Thalidomide-Piperazine-Piperidine hydrochloride（Cat No.:I044479）is a multifunctional compound integrating three pharmacophores: thalidomide, known for immunomodulatory and anti-angiogenic effects; piperazine, often used to enhance solubility and bioavailability; and piperidine, a common scaffold in CNS-active agents. This hybrid molecule is primarily utilized in the design of PROTACs (proteolysis-targeting chimeras), enabling selective degradation of target proteins by recruiting E3 ligases. The hydrochloride salt form improves its aqueous stability and solubility, making it suitable for advanced drug development and biochemical research into targeted therapies, particularly in oncology and neurodegenerative disease models.
| CAS Number | 2599846-44-1 |
| Synonyms | 2-(2,6-dioxopiperidin-3-yl)-5-(4-piperidin-4-ylpiperazin-1-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C22H28ClN5O4 |
| Purity | ≥95% |
| IUPAC Name | 2-(2,6-dioxopiperidin-3-yl)-5-(4-piperidin-4-ylpiperazin-1-yl)isoindole-1,3-dione;hydrochloride |
| InChI | InChI=1S/C22H27N5O4.ClH/c28-19-4-3-18(20(29)24-19)27-21(30)16-2-1-15(13-17(16)22(27)31)26-11-9-25(10-12-26)14-5-7-23-8-6-14;/h1-2,13-14,18,23H,3-12H2,(H,24,28,29);1H |
| InChIKey | KSERQHVRIGYCSY-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)C5CCNCC5.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
