Thalidomide-Piperazine-PEG3-COOH

• CAT Number: I044482
• CAS Number: 2797619-63-5
• Molecular Formula: C26H34N4O9
• Molecular Weight: 546.57
• Purity: ≥95%
• Synonyms: 3-[2-[2-[2-[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazin-1-yl]ethoxy]ethoxy]ethoxy]propanoic acid
• InChI: InChI=1S/C26H34N4O9/c31-22-4-3-21(24(34)27-22)30-25(35)19-2-1-18(17-20(19)26(30)36)29-8-6-28(7-9-29)10-12-38-14-16-39-15-13-37-11-5-23(32)33/h1-2,17,21H,3-16H2,(H,32,33)(H,27,31,34)
• InChIKey: KQWKQFKAFTXKFT-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CCOCCOCCOCCC(=O)O

Thalidomide-Piperazine-PEG3-COOH（Cat No.:I044482）is a multifunctional linker molecule widely used in the construction of PROTACs and other targeted therapeutic agents. It incorporates a thalidomide unit for cereblon E3 ligase recruitment, a piperazine ring that offers enhanced solubility and conformational flexibility, and a PEG3 (triethylene glycol) spacer that improves hydrophilicity and reduces non-specific interactions. The terminal carboxylic acid group facilitates covalent coupling to amine-containing ligands or drug warheads. This design allows for optimal spatial arrangement between functional moieties, supporting efficient and selective protein degradation in drug discovery and chemical biology research.