Thalidomide-Piperazine-PEG2-NH2 diTFA

• CAT Number: I044478
• Molecular Formula: C27H33F6N5O10
• Molecular Weight: 701.57
• Purity: ≥95%
• Synonyms: 5-[4-[2-[2-(2-aminoethoxy)ethoxy]ethyl]piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C23H31N5O6.2C2HF3O2/c24-5-11-33-13-14-34-12-10-26-6-8-27(9-7-26)16-1-2-17-18(15-16)23(32)28(22(17)31)19-3-4-20(29)25-21(19)30;2*3-2(4,5)1(6)7/h1-2,15,19H,3-14,24H2,(H,25,29,30);2*(H,6,7)
• InChIKey: VTSRBWIJOVXEKY-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CCOCCOCCN.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Thalidomide-Piperazine-PEG2-NH2 diTFA（Cat No.:I044478）is a PROTAC-compatible linker molecule featuring a thalidomide-derived cereblon (CRBN) ligand, a piperazine spacer, and a PEG2 (diethylene glycol) chain terminating in a reactive amine group for conjugation. The compound’s design enhances solubility, flexibility, and optimal spatial orientation for efficient ternary complex formation in targeted protein degradation. The diTFA (ditrifluoroacetate) salt form ensures stability and ease of handling during synthesis. This molecule is widely used in the development of CRBN-recruiting bifunctional degraders in chemical biology, supporting research into selective protein degradation and drug discovery.