For research use only. Not for therapeutic Use.
Thalidomide-Piperazine-PEG2-COOH（Cat No.:I044481）is a synthetic bifunctional linker designed for targeted protein degradation applications, particularly in PROTAC development. It features a thalidomide moiety for cereblon E3 ligase recruitment, a piperazine ring for improved solubility and conformational flexibility, and a PEG2 (diethylene glycol) spacer that enhances aqueous solubility and reduces steric hindrance. The terminal carboxylic acid group allows for easy conjugation to amine-bearing ligands or drugs. This modular design supports efficient synthesis of multifunctional molecules in chemical biology, enabling precise control over spatial orientation in drug-target interactions.
| CAS Number | 2797430-20-5 |
| Synonyms | 3-[2-[2-[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazin-1-yl]ethoxy]ethoxy]propanoic acid |
| Molecular Formula | C24H30N4O8 |
| Purity | ≥95% |
| IUPAC Name | 3-[2-[2-[4-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]piperazin-1-yl]ethoxy]ethoxy]propanoic acid |
| InChI | InChI=1S/C24H30N4O8/c29-20-4-3-19(22(32)25-20)28-23(33)17-2-1-16(15-18(17)24(28)34)27-8-6-26(7-9-27)10-12-36-14-13-35-11-5-21(30)31/h1-2,15,19H,3-14H2,(H,30,31)(H,25,29,32) |
| InChIKey | OGNGTOMKTTVHQM-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CCOCCOCCC(=O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
