Thalidomide-Piperazine-PEG1-NH2 diTFA

• CAT Number: I044477
• Molecular Formula: C25H29F6N5O9
• Molecular Weight: 657.52
• Purity: ≥95%
• Synonyms: 5-[4-[2-(2-aminoethoxy)ethyl]piperazin-1-yl]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;2,2,2-trifluoroacetic acid
• InChI: InChI=1S/C21H27N5O5.2C2HF3O2/c22-5-11-31-12-10-24-6-8-25(9-7-24)14-1-2-15-16(13-14)21(30)26(20(15)29)17-3-4-18(27)23-19(17)28;2*3-2(4,5)1(6)7/h1-2,13,17H,3-12,22H2,(H,23,27,28);2*(H,6,7)
• InChIKey: HLMGNQKEBMHMHG-UHFFFAOYSA-N
• SMILES: C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)N4CCN(CC4)CCOCCN.C(=O)(C(F)(F)F)O.C(=O)(C(F)(F)F)O

Thalidomide-Piperazine-PEG1-NH2 diTFA（Cat No.:I044477）is a functionalized cereblon (CRBN)-binding ligand designed for PROTAC (proteolysis-targeting chimera) synthesis. It features a thalidomide-based core that binds CRBN, a piperazine spacer to enhance flexibility, and a PEG1 (monoethylene glycol) linker terminating in a primary amine for conjugation to a target ligand. The diTFA (ditrifluoroacetate) salt form improves solubility and handling during synthesis. This compound facilitates the creation of bifunctional molecules that induce selective degradation of disease-relevant proteins, making it a valuable tool in chemical biology and targeted protein degradation research for therapeutic development.