For research use only. Not for therapeutic Use.
Thalidomide-PEG5-NH2 hydrochloride (Cat No.: I042496) is a thalidomide-based compound modified with a five-unit polyethylene glycol (PEG5) linker terminating in a primary amine group. This design enhances solubility, flexibility, and biocompatibility, making it ideal for constructing PROTACs and other targeted therapeutic conjugates. The PEG5 spacer allows optimal spatial orientation for binding to target proteins and E3 ligases, such as cereblon, facilitating selective protein degradation. The hydrochloride salt form improves stability and handling, supporting its use in drug discovery, chemical biology, and medicinal chemistry research.
| CAS Number | 2703775-06-6 |
| Synonyms | 5-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;hydrochloride |
| Molecular Formula | C23H32ClN3O9 |
| Purity | ≥95% |
| InChI | InChI=1S/C23H31N3O9.ClH/c24-5-6-31-7-8-32-9-10-33-11-12-34-13-14-35-16-1-2-17-18(15-16)23(30)26(22(17)29)19-3-4-20(27)25-21(19)28;/h1-2,15,19H,3-14,24H2,(H,25,27,28);1H |
| InChIKey | BNZDMYCPKJWMFA-UHFFFAOYSA-N |
| SMILES | C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C=C(C=C3)OCCOCCOCCOCCOCCN.Cl |
| Reference | [1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1005. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
